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Inoculated into oblivion | page 1, 2

At a hearing he called to coincide with the Mall rally, Rep. Dan Burton, R-Indiana, invited three panels of witnesses to speak before his Government Reform Committee. The panels were stacked with parents and researchers who believe that vaccines cause autism. Strangely absent were mainstream autism researchers and vaccine experts.

By some odd and tragic coincidence, both Burton and Helen Chenoweth, another fire-breathing, anti-government Republican on the committee, are both grandparents of autistic boys who appeared to be developing normally until they received measles-mumps-rubella and other combination vaccines when they were 15 months old.

The annals of autism research make it clear that a subset of autistic children suddenly regressed at this age long before the measles vaccine became available. But tell that to a parent whose kid goes from bubbly chatmeister to howling mute.

"I and my daughter truly believe this," Burton said at Thursday's hearing. "I just can't believe it wasn't related to the vaccine. When people tell me it's a genetic problem, I'll tell you -- that's just nuts."

"This hearing was called to establish the point of view of the chairman who believes there's a connection between autism and vaccination," countered Henry Waxman of California, the lead Democrat on the committee. "But why should we scare people about immunization until we know the facts?"

Burton's first witnesses were Andrew Wakefield of Scotland and John O'Leary of Ireland, who believe they have shown that autistic children suffering from gastrointestinal problems have measles viruses colonizing immune cells in their guts.

Wakefield, a gastroenterologist, said this suggests that a subset of autistic people may suffer brain inflammation resulting from infections that began in their intestines after they were inoculated with the measles-mumps-rubella (MMR) vaccine.

The vaccine community bitterly contests Wakefield's measles claims. Brent Taylor, who, like Wakefield, serves at the Royal Free Hospital in London, completed a study this year that showed no epidemiological evidence for a measles vaccine-autism link.

Wakefield's studies of the measles vaccine, which appeared in the Lancet, have received enormous press attention in the United Kingdom. Frightened Britons have kept their kids away from the measles "jab," and rates of vaccination against the highly contagious disease fell to about 85 percent last year.

Epidemiologists have been predicting a measles epidemic to result and this week got some confirmation: Ireland reported an outbreak of 300 measles cases, compared to only 30 in all of 1999. Two of the new cases were infants who had to be hospitalized with pneumonia complications.

"My fear," says Benjamin Schwartz of the CDC's immunization program, "is that we could get the same thing here."

Wakefield acknowledges that his is a hypothesis. But he and other researchers believe the public health bureaucracy is circling the wagons around the vaccination program -- a priority of the Clinton administration -- and should put some research money into the question.

Government scientists are skeptical. Wakefield has refused to share his tissue samples with the CDC and "we don't see a credible hypothesis to test," says Schwartz. Noting that most of the data presented by Wakefield and O'Leary is unpublished, he added, "There's a danger in reporting scientific findings at a congressional hearing."

For Schwartz and many others, the fact that a significant portion of autistic kids regress into silence shortly after their MMR shots is just a sad coincidence. "That's not a very easy explanation for a parent devastated by this disease, and I think it points out the importance of us finding a scientific reason why children are autistic," he says.

A small group of scientists hypothesize that low-grade infections caused by live viruses in MMR and other vaccines may overwhelm the immune systems of a small percentage of toddlers. Proving this requires complex experiments in an arcane field called neuroimmunology.

Neurologist Candace Pert and her virologist husband Michael Ruff, co-directors of Georgetown University's Institute For New Medicine, are members of this cutting edge, or fringe, as the case may be. They step lively where most scientists fear to tread.

The idea that vaccines, arguably the top public health achievement of the past half century, are damaging children "is such a horrible possibility, or in my eyes a high probability, that no one wants to be associated with it," Pert says. "And that's tragic because it's all been done in the name of good. But it has to be pinned down. It's too important to be just a philosophical debate."
salon.com | April 13, 2000

 

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About the writer
Arthur Allen writes on health, science and other issues for Salon. He lives in Washington.

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